clinical data

Retatrutide Facts You Should Know

TRIPLE HORMONE ACTION
Activates GLP-1, GIP and glucagon receptors to influence appetite regulation, glucose metabolism, fat metabolism and energy expenditure.

SUPPORTS METABOLIC FUNCTION
Research indicates potential benefits on metabolic pathways involved in body-weight regulation and energy balance.

INFLUENCES ENERGY BALANCE
May increase energy expenditure and fat oxidation in various preclinical and clinical models.

APPETITE REGULATION PATHWAYS
Acts on mechanisms that may help reduce hunger and food intake in research settings.

GLYCEMIC CONTROL PATHWAYS
Shown to have potential for improving glucose handling in clinical studies.

CARDIOVASCULAR MARKERS
Clinical research has evaluated effects on several cardiometabolic markers.

CLINICAL RESEARCH
Evaluated in multiple randomized, double-blind, placebo-controlled clinical trials.

MULTIPLE SYSTEMS APPROACH
Targets several physiological systems involved in metabolic regulation.

Clinical Trial Results — Summary

Mean Body Weight Reduction
Up to 24.2% mean reduction at 48 weeks with the 12 mg dose in the Phase 2 obesity trial.

Mean Relative Reduction in Liver Fat
Up to 86% mean relative reduction in liver fat at 48 weeks with the 12 mg dose in the Phase 2a liver study.*

Mean Reduction in HbA1c
Up to 1.9% mean reduction in HbA1c at 48 weeks with the 12 mg dose in participants with type 2 diabetes.

Mean Increase in Heart Rate
Approximately 2–3 bpm increase from baseline at 48 weeks.

Safety Profile
The most common adverse events were gastrointestinal, including nausea, diarrhoea, vomiting and constipation. Most events were mild to moderate and dose-related. Dose-dependent increases in heart rate were also observed.

*Liver fat was measured by MRI-PDFF in a subset of participants.

TIRZEPATIDE — FACTS YOU SHOULD KNOW

Tirzepatide is a once-weekly dual GIP and GLP-1 receptor agonist. Clinical trials have demonstrated substantial improvements in body weight and several cardiometabolic measures in adults with obesity or overweight and weight-related complications.

DUAL HORMONE ACTION
Activates GIP and GLP-1 receptors to support multiple pathways involved in appetite regulation, glucose control and metabolism.

SIGNIFICANT WEIGHT IMPROVEMENT
Clinical trials show meaningful reductions in body weight across multiple doses.

SUPPORTS METABOLIC HEALTH
Associated with improvements in blood sugar control, blood pressure, lipids and other cardiometabolic risk factors.

HELPS REDUCE APPETITE
Supports a longer-lasting feeling of fullness, helping to reduce hunger and food cravings.

CLINICALLY STUDIED
Extensively evaluated in large, randomized, double-blind, placebo-controlled clinical trials in adults with obesity or overweight.

OVERALL WELLBEING
Improvements in weight and metabolic markers can contribute to better energy, mobility and quality of life.

CLINICAL TRIAL RESULTS — SURMOUNT-1

Mean Body Weight Reduction
Up to 22.5% mean reduction at 72 weeks with the 15 mg dose.*

Participants Achieving ≥20% Weight Reduction
62.9% of participants receiving the 15 mg dose at 72 weeks.*

Blood Pressure
Mean reduction of 8.1 mmHg in systolic blood pressure from baseline at 72 weeks with the 15 mg dose.*

Triglycerides
Mean reduction of 27.6% from baseline at 72 weeks with the 15 mg dose.*

Prediabetes — Return to Normoglycaemia
95.3% of tirzepatide-treated participants versus 61.9% receiving placebo at 72 weeks.†

Safety and Tolerability
The most common side effects were gastrointestinal, including nausea, diarrhoea, vomiting and constipation. They were generally mild to moderate and decreased over time.

Study design: Results from randomized, double-blind, placebo-controlled clinical trials in adults with obesity or overweight.

* At 72 weeks with the 15 mg dose.
† Among participants with prediabetes at baseline.

NAD+ — FACTS YOU SHOULD KNOW

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme naturally present in every cell. It is involved in many biological processes including energy metabolism and DNA maintenance.

SUPPORTS CELLULAR ENERGY
NAD+ is involved in mitochondrial energy pathways that help convert nutrients into usable energy.

SUPPORTS DNA MAINTENANCE
NAD+ activates enzymes involved in DNA repair and supports genomic stability.

INVOLVED IN CELLULAR AGING PROCESSES
NAD+ levels naturally decline with age. Maintaining adequate levels may be important for cellular function.

SUPPORTS MITOCHONDRIAL FUNCTION
Plays a role in mitochondrial biogenesis and efficiency for cellular energy production.

SUPPORTS NEUROLOGICAL FUNCTION
NAD+ is involved in pathways linked to neuronal health and cognitive processes.

INVOLVED IN METABOLIC PROCESSES
Participates in metabolic pathways including glucose metabolism and lipid regulation.

SUPPORTS CARDIOVASCULAR FUNCTION
Supports normal function of blood vessels and cardiovascular tissue.

HIGH PURITY FORMULA
Manufactured to high standards to ensure purity and consistency.

AT A GLANCE — RESEARCH SUMMARY

Cellular Energy
Involved in ATP production and energy metabolism.

DNA Repair
Activates sirtuins and PARPs.

Mitochondrial Function
Supports mitochondrial biogenesis and efficiency.

Cognitive Function
Associated with neuronal health and mental clarity.

Metabolic Health
Plays a role in glucose and lipid metabolism.

Cardiovascular Support
Supports healthy blood vessels and heart function.

Purity & Quality
High purity, quality-assured manufacturing.

Research is ongoing. Individual results may vary.

GHK-CU — FACTS YOU SHOULD KNOW

GHK-CU is a naturally occurring copper-binding tripeptide that has been the subject of scientific research for its potential roles in cellular processes.

STUDIED FOR SKIN RESEARCH
Investigated in studies exploring its effects on skin appearance and skin matrix components.

HAIR RESEARCH
Evaluated in studies related to hair follicle activity and hair condition.

CELLULAR RESEARCH
Studied for its involvement in cellular communication and natural repair processes.

ANTI-INFLAMMATORY PATHWAYS
Research indicates involvement in pathways related to the body's inflammatory response.

COLLAGEN & ELASTIN RESEARCH
Investigated in studies on collagen synthesis and elastin modulation in cell and tissue models.

TISSUE REPAIR MODELS
Used in preclinical models to explore processes associated with tissue repair and regeneration.

WELLNESS RESEARCH
Included in research related to overall wellness, vitality and cellular function.

RESEARCH INSIGHTS

IMPROVED SKIN APPEARANCE
Human studies report improvements in the appearance and depth of wrinkles.

IMPROVED SKIN DENSITY & THICKNESS
Topical GHK-CU has been associated with improved skin density, thickness and firmness.

INCREASED COLLAGEN PRODUCTION
In a human study, increased collagen production was observed in a majority of participants using a topical GHK-CU formulation.

HAIR HEALTH RESEARCH
Research suggests GHK-CU may be involved in hair growth and improve hair calibre (thickness).

ANTI-INFLAMMATORY RESEARCH
Preclinical research indicates GHK-CU may modulate inflammatory pathways and reduce inflammatory markers.

COLLAGEN & ELASTIN SYNTHESIS
Laboratory studies show GHK-CU can stimulate the synthesis of collagen, elastin and other extracellular matrix components.

TISSUE REPAIR & RECOVERY MODELS
Preclinical studies indicate GHK-CU supports tissue repair and recovery processes.

SAFETY IN STUDIES
Human studies report that topical GHK-CU was well tolerated with minimal adverse effects.

AT A GLANCE — RESEARCH SUMMARY

Skin Research — Studied in relation to skin appearance and matrix components.

Hair Research — Evaluated in studies on hair growth and condition.

Cellular Research — Involved in cellular communication and repair processes.

Inflammatory Pathways — Investigated for its role in inflammatory responses.

Collagen & Elastin — Shown to influence collagen and elastin synthesis in models.

Tissue Repair Models — Explored in models of tissue repair and recovery.

Wellness Research — Included in studies on wellness and vitality.

THE GLOW TRIO

Science-Focused Peptides. Research-Driven Potential.

The Glow Trio combines three well-researched peptides — GHK-CU, TB-500 and BPC-157. Each has been the subject of scientific investigation for their potential roles in cellular processes and tissue modulation.

GHK-CU — Copper Peptide

GHK-CU is a naturally occurring copper-binding tripeptide that has been widely studied for its involvement in cellular communication and extracellular matrix processes.

STUDIED IN SKIN RESEARCH
Investigated in studies exploring its effects on skin appearance and extracellular matrix components.

HAIR RESEARCH
Evaluated in studies related to hair follicle activity and hair condition.

CELLULAR REPAIR PROCESSES
Studied for its involvement in natural repair mechanisms at the cellular level.

INFLAMMATORY PATHWAYS
Research indicates involvement in modulating inflammatory pathways.

COLLAGEN & ELASTIN RESEARCH
Investigated in studies on collagen and elastin production in cellular and tissue models.

Research Highlights

• Studied in human and in vitro models

• Involved in extracellular matrix processes

• Evaluated in skin and hair research

• Investigated for anti-inflammatory roles

• Examined for collagen and elastin synthesis

TB-500 — Thymosin Beta-4

TB-500 is a synthetic version of a naturally occurring protein fragment that has been the subject of research for its role in actin regulation and cellular processes.

CELLULAR MIGRATION STUDIES
Researched for its role in cellular migration in various experimental models.

TISSUE REPAIR RESEARCH
Investigated in studies related to tissue repair mechanisms.

INFLAMMATORY RESPONSE
Studied for its effects on inflammatory responses in preclinical research.

MUSCLE & TENDON RESEARCH
Evaluated in studies involving muscle and tendon models.

JOINT RESEARCH
Investigated in preclinical studies implicating joint health.

Research Highlights

• Explored in tissue repair research

• Studied in cellular migration models

• Evaluated in muscle, tendon and joint research

• Investigated for anti-inflammatory effects

• Examined in various preclinical studies

BPC-157 — Body Protection Compound

BPC-157 is a synthetic peptide derived from a protein fragment that has been extensively studied in preclinical research for its wide range of biological activities.

GASTROINTESTINAL RESEARCH
Investigated in studies related to the gastrointestinal tract.

TISSUE REPAIR RESEARCH
Studied in various models for its role in tissue repair processes.

ANTI-INFLAMMATORY RESEARCH
Researched for its effects on inflammatory pathways.

NEUROPROTECTION STUDIES
Explored in preclinical studies related to neural tissue.

MUSCLE, TENDON & LIGAMENT STUDIES
Investigated in models related to muscles, tendons and ligaments.

Research Highlights

• Extensively studied in preclinical models

• Researched for tissue repair support

• Investigated in GI tract research

• Studied for anti-inflammatory activity

• Explored for neuroprotective potential

THE GLOW TRIO — COMBINED RESEARCH FOCUS

CELLULAR COMMUNICATION RESEARCH
Combined focus on cell signalling and cellular processes.

TISSUE & MATRIX RESEARCH
Investigated for roles in extracellular matrix and tissue support.

INFLAMMATORY PATHWAYS
Studied for potential involvement in inflammatory responses.

REPAIR & REGENERATION RESEARCH
Explored in research related to repair mechanisms.

PRECLINICAL DATA
Supported by a range of laboratory and preclinical studies.